Acetic Acid → HCID 178489574, 화합물

HRID 574318

반응식

HRID 574318 반응식
[N:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH3:11])=[C:2]=[S:3].C[O:13][C:14](=O)[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=1[NH2:22].C(O)(=O)C>C(O)C>[SH:3][C:2]1[N:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[O:10][CH3:11])[C:14](=[O:13])[C:15]2[C:16](=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=2)[N:22]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 5205992-Methoxyphenyl IsothiocyanateHCID 11205965Methyl 2-amino-4-methylbenzoate

생성물 1

HCID 178489574HCID 178489574, 화합물수율 62%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

1-Isothiocyanato-2-methoxy-benzene (0.76 mL, 5.45 mmol) was added to a solution of 2-amino-4-methyl-benzoic acid methyl ester (900 mg, 5.45 mmol) and acetic acid (1.5 mL) in ethanol (10 mL), and heated at reflux for 16 hr. The reaction mixture was cooled to room temperature and diluted with ethanol. The precipitated solid was filtered, washed with ethanol and dried to afford 2-mercapto-3-(2-methoxy-phenyl)-7-methyl-3H-quinazolin-4-one (1.0 g, 62%) as white solid.

후처리

  1. temperatureheated
  2. temperatureat reflux for 16 hr
  3. filtrationThe precipitated solid was filtered
  4. washwashed with ethanol
  5. customdried

출처 및 근거

ORD 기록
ord-f00a564f82cb40d49009fa43b4a6a418
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034887B2

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