Methylphenidate Hydrochloride → Methylphenidate

HRID 574653

반응식

HRID 574653 반응식
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl>O>[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

참가 물질

3

반응물 1

HCID 9280Methylphenidate Hydrochloride

생성물 1

HCID 4158Methylphenidate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a preferred manufacturing process, methylphenidate HCl and microcrystalline cellulose (Avicel PH-101) are blended in a Hobart Mixer. Purified water is added to the dry mixture and the wet granulation is extruded (MG-55 Multi granulator). The extrudate is then spheronized into pellets (Caleva Model# SPH250). The wet pellets are dried (Fluid Air Model#0050) and sieved (30 mesh<Acceptable<20 mesh).

후처리

  1. customThe wet pellets are dried (Fluid Air Model#0050)
  2. filtrationsieved (30 mesh<Acceptable<20 mesh)

출처 및 근거

ORD 기록
ord-12517afc368e49b784f3677fab99936b
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034902B2

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