Ethyl 2-isothiocyanato-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate → 3-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,6,7,8,9-hexahydro[1]-benzothieno[2,3-d]pyrimidin-4(1H)-one

HRID 574700

반응식

HRID 574700 반응식
[N:1]([C:4]1[S:8][C:7]2[CH2:9][CH2:10][CH2:11][CH2:12][C:6]=2[C:5]=1[C:13]([O:15]CC)=O)=[C:2]=[S:3].[CH3:18][C:19]1[N:23]([CH2:24][CH2:25][CH2:26][NH2:27])[CH:22]=[N:21][CH:20]=1>>[CH3:18][C:19]1[N:23]([CH2:24][CH2:25][CH2:26][N:27]2[C:13](=[O:15])[C:5]3[C:6]4[CH2:12][CH2:11][CH2:10][CH2:9][C:7]=4[S:8][C:4]=3[NH:1][C:2]2=[S:3])[CH:22]=[N:21][CH:20]=1

참가 물질

3

반응물 2

HCID 2779675Ethyl 2-isothiocyanato-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylateHCID 194294833-(5-methyl-1H-imidazol-1-yl)propan-1-amine

생성물 1

HCID 251000413-[3-(5-methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2,3,6,7,8,9-hexahydro[1]-benzothieno[2,3-d]pyrimidin-4(1H)-one

실험 절차

The compound was synthesized starting from ethyl 4,5,6,7-tetrahydro-2-isothiocyanatobenzo[b]thiophene-3-carboxylate (0.175 g. 0.66 mmol) and 3-(5-methyl-1H-imidazol-1-yl)propan-1-amine (5) (0.09 g, 0.66 mmol) as described above.

후처리

  1. customThe compound was synthesized

출처 및 근거

ORD 기록
ord-ad83d20a83cc408b886271b44f992726
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034907B2

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