4-Chloro-3-nitrobenzenesulfonamide → 3-cyano-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide

HRID 574789

반응식

HRID 574789 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+]([O-])=O.[O:15]1[CH2:20][CH2:19][CH:18]([CH2:21][NH2:22])[CH2:17][CH2:16]1.Cl.Cl.[CH3:25][N:26]1CCN(N)CC1>>[C:25]([C:3]1[CH:4]=[C:5]([S:8]([NH2:11])(=[O:10])=[O:9])[CH:6]=[CH:7][C:2]=1[NH:22][CH2:21][CH:18]1[CH2:19][CH2:20][O:15][CH2:16][CH2:17]1)#[N:26]

참가 물질

4

반응물 3

HCID 73244-Chloro-3-nitrobenzenesulfonamideHCID 1982214-Methylpiperazin-1-ylamine dihydrochloride hydrateHCID 27732104-Aminomethyltetrahydropyran

생성물 1

HCID 671265013-cyano-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide

실험 절차

The title compound was prepared by substituting EXAMPLE 52A for 4-chloro-3-nitrobenzenesulfonamide and (tetrahydro-2H-pyran-4-yl)methanamine for 4-methylpiperazin-1-amine dihydrochloride in EXAMPLE 6A.

출처 및 근거

ORD 기록
ord-048d1d1346434106a465c864006aba1f
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034875B2

연결된 노트

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