Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 574793노트

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HRID 574793 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

생성물 1

HCID 31128494-Morpholinobut-2-YN-1-OL

시약·촉매·용매 1

HCID 1140Toluene용매2회

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온도
85 °C

실험 절차

To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the pure title compound.

후처리

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

출처 및 근거

ORD 기록
ord-ad3dc5f2bf064f62b44bd5be07fb5a17
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034875B2

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