8-(Benzyloxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one → 8-(Hydroxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one

HRID 574974노트

반응식

HRID 574974 반응식
C([O:8][CH2:9][CH:10]1[CH2:20][CH2:19][C:13]2([O:17][C:16](=[O:18])[NH:15][CH2:14]2)[CH2:12][CH2:11]1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[OH:8][CH2:9][CH:10]1[CH2:20][CH2:19][C:13]2([O:17][C:16](=[O:18])[NH:15][CH2:14]2)[CH2:12][CH2:11]1

참가 물질

4

반응물 1

HCID 671267508-(Benzyloxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one

생성물 1

HCID 575765318-(Hydroxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

A solution of EXAMPLE 385B (500 mg) in ethanol was added to wet 20% palladium hydroxide on carbon (2500 mg) in a 50 ml pressure bottle. The mixture was stirred at ambient temperature for 3 hours under hydrogen at 30 psi. The mixture was filtered and concentrated to provide the title compound.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-cf6e5201980545d4baf82925829dc691
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034875B2

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