Ammonia methanol → Cyclobutylamino-9-(3-hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid amide

HRID 575109노트

반응식

C[O:2][C:3]([C:5]1[S:6][C:7]2[CH:8]([NH:25][CH:26]3[CH2:29][CH2:28][CH2:27]3)[CH2:9][O:10][C:11]3[CH:18]=[CH:17][C:16]([C:19]#[C:20][C:21]([OH:24])([CH3:23])[CH3:22])=[CH:15][C:12]=3[C:13]=2[N:14]=1)=O.CO.[NH3:32]>>[CH:26]1([NH:25][CH:8]2[C:7]3[S:6][C:5]([C:3]([NH2:32])=[O:2])=[N:14][C:13]=3[C:12]3[CH:15]=[C:16]([C:19]#[C:20][C:21]([OH:24])([CH3:23])[CH3:22])[CH:17]=[CH:18][C:11]=3[O:10][CH2:9]2)[CH2:29][CH2:28][CH2:27]1

참가 물질

반응물 2

HCID 21705897Ammonia methanol

HCID 866931394-Cyclobutylamino-9-(3-hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid methyl ester

생성물 1

HCID 71714726Cyclobutylamino-9-(3-hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid amide수율 54%

실험 절차

A solution of 4-Cyclobutylamino-9-(3-hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid methyl ester (80 mg, 0.19 mmol), in methanol-ammonia (5 mL) was stirred at room temperature for 0.5 h. Then the mixture was filtered to afford 4 Cyclobutylamino-9-(3-hydroxy-3-methyl-but-1-ynyl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid amide (42 mg, 54%) as a white solid.

후처리

filtrationThen the mixture was filtered

출처 및 근거

ORD 기록: ord-702dace33fdc43f8a48fb9fd3f5a9454
출처 데이터셋: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09034866B2

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