Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Methylamino)tetrahydro-2H-pyran → (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-((tetrahydro-2H-pyran-4-yl)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Methylamino)tetrahydro-2H-pyran | HCID 6991950 | — |
| 반응물 | (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide | HCID 86693302 | — |
| 생성물 | (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-((tetrahydro-2H-pyran-4-yl)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide | HCID 86693306 | — |
반응 단계
Prepared as described for (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide replacing 4-aminotetrahydropyran with 4-(methylamino)tetrahydropyran. Off-white solid (19.4 mg, 7%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09034866B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-f1832f7bc9f74cd3842e76a647bc3ecf |
| 출처 메모 | uspto-grants-2015_05 |