Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bis(2-bromoethyl) ether → 4-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bis(2-bromoethyl) ether | HCID 21521 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | HCID 2734655 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine | HCID 4192663 | — |
반응 단계
A solution of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine (164 mg, 0.75 mmol), 1-bromo-2-(2-bromoethoxy)ethane (418 mg, 1.8 mmol), and DIPEA (0.64 mL, 3.6 mmol) in THF (2 mL) was stirred at reflux overnight. The mixture was concentrated, diluted with water, and extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated. The residue was purified by preparative thin-layer chromatography to give the title compound. MS (m/z): 290 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434726B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-cc1fb27aad36408cadc3dd063474605a |
| 출처 메모 | uspto-grants-2016_09 |