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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0

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Triethylamine → Methyl 10-bromo-9-fluoro-3((1-methyl-1H-pyrazol-5-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate

HRID 575403

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HRID 575403 반응식

[Br:1][C:2]1[C:3]([F:29])=[CH:4][C:5]2[CH:11]3[CH2:12][CH:9]([CH2:10]3)[N:8]3[C:13]([CH:20](O)[C:21]4[N:25]([CH3:26])[N:24]=[CH:23][CH:22]=4)=[C:14]([C:16]([O:18][CH3:19])=[O:17])[N:15]=[C:7]3[C:6]=2[CH:28]=1.C(N(CC)CC)C.CS(Cl)(=O)=O>ClCCl>[Br:1][C:2]1[C:3]([F:29])=[CH:4][C:5]2[CH:11]3[CH2:10][CH:9]([CH2:12]3)[N:8]3[C:13]([CH2:20][C:21]4[N:25]([CH3:26])[N:24]=[CH:23][CH:22]=4)=[C:14]([C:16]([O:18][CH3:19])=[O:17])[N:15]=[C:7]3[C:6]=2[CH:28]=1

참가 물질 실험 절차 후처리 출처 및 근거 반응 노트

참가 물질

5

반응물 3

HCID 8471Triethylamine

HCID 31297Methanesulfonyl chloride

HCID 86693448Methyl 10-bromo-9-fluoro-3-(hydroxy(1-methyl-1H-pyrazol-5-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate

생성물 1

HCID 86693454Methyl 10-bromo-9-fluoro-3((1-methyl-1H-pyrazol-5-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate

시약·촉매·용매 1

HCID 6344

Dichloromethane

용매

실험 절차

To a solution of methyl 10-bromo-9-fluoro-3-(hydroxy(1-methyl-1H-pyrazol-5-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate (140 mg, 0.3035 mmol) in dichloromethane (0.91 mL) was added triethylamine (4.0 equiv., 0.171 mL, 1.214 mmol) followed by methanesulfonyl chloride (1.2 equiv., 0.029 mL, 0.3642 mmol). The reaction was stirred at room temperature until LC/MS analysis indicated complete consumption of starting material.

후처리

customconsumption of starting material

출처 및 근거

ORD 기록: ord-31b30e9136cb476bb5ed0d10aa8ea1a6
출처 데이터셋: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09034866B2

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