Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylsilyl isocyanate → (R)-tert-butyl 3-ureidopyrrolidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylsilyl isocyanate | HCID 70696 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (R)-(+)-1-Boc-3-aminopyrrolidine | HCID 854070 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (R)-tert-butyl 3-ureidopyrrolidine-1-carboxylate | HCID 71113416 | — |
반응 단계
To a solution of (R)-tert-butyl 3-aminopyrrolidine-1-carboxylate (180 mg, 1 mmol) in dichloromethane was added TMS-NCO (1 g, 8.7 mmol) and DIPEA (1.2 g, 10 mmol). The mixture was stirred at room temperature overnight, then was concentrated in vacuo. The residue was treated with EtOAc/H2O, the organic layer was combined, washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated to give the crude title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434726B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-03b908eb6c974305becfdd62d3cb84c4 |
| 출처 메모 | uspto-grants-2016_09 |