참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-5-nitropyridine | HCID 78240 | — |
| 반응물 | 4-(Methylamino)tetrahydro-2H-pyran | HCID 6991950 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine | HCID 71113503 | — |
반응 단계
To a solution of N-methyltetrahydro-2H-pyran-4-amine (172.5 mg, 1.5 mmol) in CH3CN (5 mL) was added K2CO3 (207 mg, 1.5 mmol) and 2-bromo-5-nitropyridine (203 mg, 1 mmol). The reaction was stirred at 80° C. for 16 hours. TLC and LC-Ms showed the reaction had completed and the reaction was poured into water, extracted with EA, washed with water and brine, dried and concentrated to give a yellow solid. MS (m/z): 238 (M+H)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09434726B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-60fad13e37c44b7d8325cf471ccdbb2f |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
