Water → 1-(4-Bromophenoxy)-2-methylpropan-2-ol

HRID 57552

반응식

HRID 57552 반응식
Cl[CH2:2][C:3]([CH3:6])([OH:5])[CH3:4].C([O-])([O-])=O.[K+].[K+].[Br:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1.O>CN(C=O)C>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:2][C:3]([CH3:6])([OH:5])[CH3:4])=[CH:16][CH:15]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 78084-Bromophenol2회HCID 11430Potassium CarbonateHCID 684091-Chloro-2-methylpropan-2-ol

생성물 1

HCID 211863421-(4-Bromophenoxy)-2-methylpropan-2-ol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
140 °C

실험 절차

To a solution of 1-chloro-2-methylpropan-2-ol (434.4 mg, 4 mmol) in DMF (10 mL) was added K2CO3 (552 mg, 4 mmol) and 4-bromophenol (346 mg, 2 mmol), the reaction was stirred at 140° C. for 48 hours. About of 10% 4-bromophenol was remained and the reaction was poured into 30 mL of water, extracted with EA (20 mL×3), washed with 30 mL of water and brine, concentrated and purified on TLC (EA:PE=1:3) to give yellow solid. MS (m/z): 196 (M−50)+

후처리

  1. extractionextracted with EA (20 mL×3)
  2. washwashed with 30 mL of water and brine
  3. concentrationconcentrated
  4. custompurified on TLC (EA:PE=1:3)
  5. customto give yellow solid

출처 및 근거

ORD 기록
ord-f38fff146e104ddebbca900c771cc61a
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434726B2

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