Water → 2-Bromo-4-ethylsulfonyl-1-methoxybenzene

HRID 575572노트

반응식

HRID 575572 반응식
[Br:1][C:2]1[CH:7]=[C:6]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1F.C[O-].[Na+].O.[C:18](OCC)(=[O:20])C>C1COCC1>[Br:1][C:2]1[CH:7]=[C:6]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[O:20][CH3:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl Acetate2회HCID 10942334Sodium MethoxideHCID 585219752-Bromo-4-(ethylsulfonyl)-1-fluorobenzene

생성물 1

HCID 109788092-Bromo-4-ethylsulfonyl-1-methoxybenzene수율 79.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 2-bromo-4-ethylsulfonyl-1-fluorobenzene (0.6 g, 2.25 mmol) and sodium methoxide (1.2 g, 22.2 mmol) in THF (20 mL) was stirred at room temperature for 18 h. Water (30 mL) was added and extractive work up with ethyl acetate followed by silica gel chromatography (PE:EA=10:1 to 1:1) gave the title compound (0.5 g, 79.4%) as a yellow solid. 1H NMR (CDCl3, 400 MHz) δ 8.08 (d, J=2.4 Hz, 1H), 7.87-7.84 (dd, J1=8.6 Hz, J2=2.4 Hz, 1H), 7.04 (d, J=8.8 Hz, 1H), 3.99 (s, 3H), 3.11 (q, J=7.4 Hz, 2H), 1.30 (t, J=7.4 Hz, 3H).

출처 및 근거

ORD 기록
ord-3cda75486fe04705801011bde5015c66
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034900B2

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