p-Bromobenzenesulfonyl chloride → 4-[(4-Bromobenzene)sulfonyl]morpholine

HRID 57561

반응식

HRID 57561 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(N(CC)CC)C.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 8083MorpholineHCID 8471Triethylamine

생성물 1

HCID 2531284-[(4-Bromobenzene)sulfonyl]morpholine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-bromobenzene-1-sulfonyl chloride (2.56 g, 10.0 mmol) and triethylamine (1.82 mL, 13 mmol) in DCM (50 mL) was added morpholine (960 mg, 11.0 mmol) dropwise and the mixture was stirred for 30 minutes at room temperature. Then the mixture was concentrated and extracted with EA, washed with 0.1M HCl water solution (2×100 mL), NaHCO3 solution (2×100 mL) and brine, dried and concentrated to give product as a white solid.

후처리

  1. concentrationThen the mixture was concentrated
  2. extractionextracted with EA
  3. washwashed with 0.1M HCl water solution (2×100 mL), NaHCO3 solution (2×100 mL) and brine
  4. customdried
  5. concentrationconcentrated
  6. customto give product as a white solid

출처 및 근거

ORD 기록
ord-9433996ce9ba462fa4ebac1f06a03aee
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434726B2

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