Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Methyl 1-(4-nitrophenyl)piperidine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | p-Fluoronitrobenzene | HCID 9590 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl isonipecotate | HCID 424914 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Methyl 1-(4-nitrophenyl)piperidine-4-carboxylate | HCID 345002 | 58.6% |
반응 단계
A solution of 1-fluoro-4-nitrobenzene (3.5 g, 24.81 mmol), methyl piperidine-4-carboxylate (4.26 g, 29.77 mmol) and K2CO3 in 40 mL of ACN, was stirred at reflux overnight. The mixture was added to 150 mL of water, extracted with EA, dried over Na2SO4. The volatiles were removed in vacuo, and the residue was purified by chromatography with PE/EA (10:1˜2:1) to give 3.84 g of methyl 1-(4-nitrophenyl)piperidine-4-carboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434726B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-c3d4a95262ab4a52a41411a3f3da7c02 |
| 출처 메모 | uspto-grants-2016_09 |