Dibenzylamine → 2-(3-(Dibenzylamino)-2-hydroxypropyl)isoindoline-1,3-dione

HRID 57595노트

반응식

HRID 57595 반응식
[O:1]1[CH2:3][CH:2]1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15].[CH2:16]([NH:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CCO>[CH2:24]([N:23]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3][CH:2]([OH:1])[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

참가 물질

4

반응물 2

HCID 7656DibenzylamineHCID 21601N-(2,3-Epoxypropyl)phthalimide

생성물 1

HCID 104086942-(3-(Dibenzylamino)-2-hydroxypropyl)isoindoline-1,3-dione수율 56.2%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of 2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (4.06 g, 20.0 mmol) and dibenzylamine (5.0 g, 25.4 mmol) was stirred at 80° C. overnight. EtOH (50 mL) was added, and stirred at room temperature. The mixture was filtered to give white solid (4.5 g).

후처리

  1. stirringstirred at room temperature
  2. filtrationThe mixture was filtered

출처 및 근거

ORD 기록
ord-b2a2f15a0b8848bb82600afc499c63de
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434726B2

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