4-methyl-8-nitro-2H-1,4-benzoxazin-3(4H)-one → 8-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one

HRID 576074노트

반응식

HRID 576074 반응식
[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([N+:12]([O-])=O)[C:6]=2[O:5][CH2:4][C:3]1=[O:15]>C(O)C.[Pd]>[NH2:12][C:11]1[C:6]2[O:5][CH2:4][C:3](=[O:15])[N:2]([CH3:1])[C:7]=2[CH:8]=[CH:9][CH:10]=1

참가 물질

4

반응물 1

HCID 389971764-methyl-8-nitro-2H-1,4-benzoxazin-3(4H)-one

생성물 1

HCID 263703078-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one수율 88.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 4-methyl-8-nitro-2 H-1,4-benzoxazin-3(4 H)-one (415 mg, 1.99 mmol) in ethanol (10 mL) was added 10% palladium activated carbon (415 mg) at room temperature, and the mixture was stirred overnight under a hydrogen atmosphere. The reaction mixture was filtered through Celite (registered trademark), followed by washing with ethanol. The filtrate was concentrated under reduced pressure. The resulting residue was dried under reduced pressure to afford the title compound as a gray powder (314 mg).

후처리

  1. filtrationThe reaction mixture was filtered through Celite (registered trademark)
  2. washby washing with ethanol
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customThe resulting residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-862f18eab74f4ad4bcf8f898dc1d921c
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09035059B2

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