Cesium carbonate → N-(6-ethoxy-5-(trifluoromethyl)pyridin-3-yl)-2-(4-(5-ethoxy-6-((4-me thoxybenzyl)oxy)pyridin-3-yl)-2-fluorophenyl)acetamide

반응식

[CH2:1]([O:3][C:4]1[C:5]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)=[N:6][CH:7]=[C:8](B2OC(C)(C)C(C)(C)O2)[CH:9]=1)[CH3:2].Br[C:30]1[CH:35]=[CH:34][C:33]([CH2:36][C:37]([NH:39][C:40]2[CH:41]=[N:42][C:43]([O:50][CH2:51][CH3:52])=[C:44]([C:46]([F:49])([F:48])[F:47])[CH:45]=2)=[O:38])=[C:32]([F:53])[CH:31]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[CH2:51]([O:50][C:43]1[N:42]=[CH:41][C:40]([NH:39][C:37](=[O:38])[CH2:36][C:33]2[CH:34]=[CH:35][C:30]([C:8]3[CH:7]=[N:6][C:5]([O:19][CH2:20][C:21]4[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=4)=[C:4]([O:3][CH2:1][CH3:2])[CH:9]=3)=[CH:31][C:32]=2[F:53])=[CH:45][C:44]=1[C:46]([F:47])([F:49])[F:48])[CH3:52]