HCID 59163141, 화합물 → tert-Butyl (3S)-3-acetylpyrrolidine-1-carboxylate
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CON(C)[C:4]([C@H:6]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7]1)=[O:5].[CH3:19][Mg]Br>C1COCC1>[C:4]([C@H:6]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:12])[CH2:7]1)(=[O:5])[CH3:19]참가 물질
4
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- 온도
- 0 °C
실험 절차
To a solution of (S)-tert-butyl 3-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate in THF (18 mL) was added methylmagnesium bromide (in ether, 3 M, 2.7 mL) at 0° C. The mixture was stirred at 0° C. for 2 hours, then quenched with saturated aqueous NH4Cl, and extracted with Et2O. The combined extracts were washed with saturated aqueous NaHCO3, dried over Na2SO4, filtered, and concentrated to give the tile compound for the next step.
후처리
- customquenched with saturated aqueous NH4Cl
- extractionextracted with Et2O
- washThe combined extracts were washed with saturated aqueous NaHCO3
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- customto give the tile compound for the next step
출처 및 근거
- ORD 기록
- ord-cf7fdb567c864b6a9533f641a5ca7db8
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434726B2
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