Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Orcinol → ethyl 7-bromo-3-(3-(3-hydroxy-5-methylphenoxy)propyl)-1H-indole-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Orcinol | HCID 10436 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Dibenzyl azodicarboxylate | HCID 5387121 | — |
| 반응물 | ethyl 7-bromo-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylate | HCID 68938945 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | ethyl 7-bromo-3-(3-(3-hydroxy-5-methylphenoxy)propyl)-1H-indole-2-carboxylate | HCID 68939274 | — |
반응 단계
A suspension of ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate (EXAMPLE 1C) (0.9 g), 5-methylbenzene-1,3-diol (1.028 g), triphenylphosphine (0.868 g), dibenzylazodicarboxylate (0.762 g) and tetrahydrofuran (40 ml) was stirred at room temperature for 19 hours. After removal of the solvent, the crude product was purified by flash chromatography silica gel, (Analogix, SF65-200 g) eluting with 0-10% ethyl acetate in hexane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09035047B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-547b6bf38b4e417aa28a5e9355d2cbd1 |
| 출처 메모 | uspto-grants-2015_05 |