Acetyl chloride → HCID 53239786, 화합물

HRID 576487노트

반응식

HRID 576487 반응식
[C:1]([NH:4][C@H:5]1[C@H:14]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[O:13][C:8]([OH:12])([C:9](=[O:11])[OH:10])[CH2:7][C@@H:6]1[OH:21])(=[O:3])[CH3:2].[C:22](Cl)(=O)[CH3:23]>C(O)C>[C:1]([NH:4][C@H:5]1[C@H:14]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[O:13][C:8]([OH:12])([C:9](=[O:10])[O:11][CH2:22][CH3:23])[CH2:7][C@@H:6]1[OH:21])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 439197N-Acetyl-Neuraminic Acid

생성물 1

HCID 53239786HCID 53239786, 화합물수율 91.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of N-acetyl-neuraminic acid (1 g, 3.23 mmole) in anhydrous ethanol (75 ml) was added 1.5 ml acetyl chloride. The mixture was sealed and stirred at room temperature for 16 hrs. to form a clear solution. The resulting solution was vacuum evaporated to dryness. The white solid was washed with ethyl acetate and vacuum dried to afford the title compound as a white solid (1 g, 91.7%).

후처리

  1. customThe mixture was sealed
  2. customto form a clear solution
  3. customevaporated to dryness
  4. washThe white solid was washed with ethyl acetate and vacuum
  5. customdried

출처 및 근거

ORD 기록
ord-7f9e2d549f6443b1a1bdd998a8751f4c
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040503B2

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