Sodium Iodide → 2-(3-(4-(5-Chloro-2-methylphenyl)piperazin-1-yl)propyl)isoindoline-1,3-dione

HRID 576505노트

반응식

HRID 576505 반응식
Br[CH2:2][CH2:3][CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:15].[Na+].[I-].[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([CH3:31])=[C:23]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:24]=1>CC(C)=O>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([CH3:31])=[C:23]([N:25]2[CH2:26][CH2:27][N:28]([CH2:2][CH2:3][CH2:4][N:5]3[C:13](=[O:14])[C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[C:6]3=[O:15])[CH2:29][CH2:30]2)[CH:24]=1

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 21611N-3-BromopropylphthalimideHCID 693767N-(5-Chloro-2-methylphenyl)piperazine

생성물 1

HCID 585388742-(3-(4-(5-Chloro-2-methylphenyl)piperazin-1-yl)propyl)isoindoline-1,3-dione수율 81%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 2-(3-bromopropyl)isoindoline-1,3-dione (2.68 g, 10 mmol) and NaI (20 mmol) in acetone was refluxed for 5 h, then to it was added 1-(5-chloro-2-methylphenyl)piperazine (2.11 g, 10.0 mmol). The reflux was continued for 12 h. Reaction was then cooled to room temperature, filtered through celite and concentrated. The crude product was recrystallized from acetone to give the title compound as a white solid (3.21 g, 81%).

후처리

  1. temperaturewas refluxed for 5 h
  2. customReaction
  3. filtrationfiltered through celite
  4. concentrationconcentrated
  5. customThe crude product was recrystallized from acetone

출처 및 근거

ORD 기록
ord-23c411aacfc14b86ba59836a7cfc6d95
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040508B2

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