Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 57660생성일: 2026년 10월 24일
Phenol → 5-methyl-7-neopentyl-3-phenoxy-2-(4-(pyridin-4-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
https://huagongshe.com/ko/reaction/57660
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 3-chloro-5-methyl-7-neopentyl-2-(4-(pyridin-4-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | HCID 70095330 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-methyl-7-neopentyl-3-phenoxy-2-(4-(pyridin-4-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | HCID 54760862 | 67.3% |
반응 단계
3-chloro-5-methyl-7-neopentyl-2-(4-(pyridin-4-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (30 mg, 0.069 mmol), potassium carbonate (29 mg, 0.2 mmol) and phenol (20 mg, 0.20 mmol) are placed in a Biotage microwave vial, and then 0.3 mL of dioxane is added. The vial is sealed, and then heated in a Biotage microwave instrument at 150° C. for 3 h. The reaction mixture is diluted with DMF, and then filtered. The filtrate is purified with a semi-preparative HPLC to give 23 mg of pure product as pale yellow solids. MS (ESI) m/z 496.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09434730B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-7f11b9f4243f47f5a2b3cfcdd833e3ee |
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| 출처 메모 | uspto-grants-2016_09 |
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