Sodium Bicarbonate → tert-butyl 3-ethoxy-5,6-dihydropyrazine-1(2H)-carboxylate

HRID 576687노트

반응식

HRID 576687 반응식
[O:1]=[C:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:3]1.F[B-](F)(F)F.[CH2:20]([O+](CC)CC)[CH3:21].C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH2:20]([O:1][C:2]1[CH2:3][N:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:5][CH2:6][N:7]=1)[CH3:21]

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 2723982Triethyloxonium tetrafluoroborateHCID 3157178Tert-butyl 3-oxopiperazine-1-carboxylate

생성물 1

HCID 67439401tert-butyl 3-ethoxy-5,6-dihydropyrazine-1(2H)-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl 3-oxopiperazine-1-carboxylate (1 g, 5 mmol) in DCM (15 mL) was added triethyloxonium tetrafluoroborate (2.9 g, 15 mmol). Stirred for 2 h and neutralized with sat. aq NaHCO3. Layers separated and aqueous layer extracted with DCM. Combined organic layers dried over Na2SO4, filtered, and concentrated to give the title compound, which was used directly without further purification.

후처리

  1. customLayers separated
  2. extractionaqueous layer extracted with DCM
  3. dry with materialCombined organic layers dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-35496499ef744be4bf4ed12ae41b64c8
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040534B2

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