Nitric Acid → HCID 86723852, 화합물

HRID 576754노트

반응식

HRID 576754 반응식
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[CH3:10][C:11]1[N:16]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:15](=[O:27])[N:14]([CH2:28][CH2:29][CH3:30])[C:13](=[O:31])[CH:12]=1>>[CH3:10][C:11]1[N:16]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[C:15](=[O:27])[N:14]([CH2:28][CH2:29][CH3:30])[C:13](=[O:31])[C:12]=1[N+:6]([O-:9])=[O:7]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 867238536-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione

생성물 1

HCID 86723852HCID 86723852, 화합물

실험 절차

To concentrated sulfuric acid (2.0 ml) were added in ice bath fuming nitric acid (0.2 ml), 6-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (prepared in Reference Example 21) (200.0 mg) and the resulting mixture was stirred for three hours in ice bath. The reaction mixture was poured into ice water, and the precipitated solids were collected by filtration to afford 6-methyl-5-nitro-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (219.0 mg).

후처리

  1. filtrationthe precipitated solids were collected by filtration

출처 및 근거

ORD 기록
ord-28131b9eaba448569b8c88b0db2516e2
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040516B2

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