HCID 86723852, 화합물 → HCID 86723854, 화합물

HRID 576755노트

반응식

HRID 576755 반응식
[CH3:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C:6](=[O:18])[N:5]([CH2:19][CH2:20][CH3:21])[C:4](=[O:22])[C:3]=1[N+:23]([O-])=O>CO.O.[Pd]>[NH2:23][C:3]1[C:4](=[O:22])[N:5]([CH2:19][CH2:20][CH3:21])[C:6](=[O:18])[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:9]=2)[C:2]=1[CH3:1]

참가 물질

4

반응물 1

HCID 86723852HCID 86723852, 화합물

생성물 1

HCID 86723854HCID 86723854, 화합물수율 103.7%

시약·촉매·용매 2

HCID 23219155Palladium hydrate촉매HCID 887Methanol용매

실험 절차

To a solution of 6-methyl-5-nitro-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (200.0 mg) in methanol (10.0 ml) was added palladium hydrate (20.0 mg) and the resulting mixture was stirred at room temperature under catalytic hydrogenation condition for twelve hours. The reaction mixture was degassed and then filtered through Celite (trade mark), and then concentrated under reduced pressure to afford 5-amino-6-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (190.0 mg).

후처리

  1. customThe reaction mixture was degassed
  2. filtrationfiltered through Celite (trade mark)
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-53d5553a1d2845848b6862db8fb1d171
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040516B2

반응 노트

불러오는 중…