Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus tribromide → 2-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus tribromide | HCID 24614 | — |
| 반응물 | (1-methyl-1H-1,3-benzodiazol-2-yl)methanol | HCID 344177 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(Bromomethyl)-1-methyl-1H-benzimidazole hydrobromide | HCID 24229451 | — |
반응 단계
To a solution of (1-methyl-1H-benzimidazol-2-yl)methanol (1.1 g, 6.8 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.3 mL, 14.0 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 2-(bromomethyl)-1-methyl-1H-benzimidazole hydrobromide. The product was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09040538B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-57f3301b836a4bb08298525512a33331 |
| 출처 메모 | uspto-grants-2015_05 |