Potassium Carbonate → HCID 178429521, 화합물

HRID 577037노트

반응식

HRID 577037 반응식
Cl.[Cl:2][C:3]1[N:7]([CH3:8])[C:6]([CH2:9]Cl)=[N:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:17][C:18]1[N:23]=[C:22]([SH:24])[N:21]=[C:20]([OH:25])[CH:19]=1>CC(C)=O>[Cl:2][C:3]1[N:7]([CH3:8])[C:6]([CH2:9][S:24][C:22]2[N:21]=[C:20]([OH:25])[CH:19]=[C:18]([CH3:17])[N:23]=2)=[N:5][CH:4]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 123115195-chloro-2-(chloromethyl)-1-methyl-1H-imidazole hydrochlorideHCID 178429541HCID 178429541, 화합물

생성물 1

HCID 178429521HCID 178429521, 화합물수율 79%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

5-chloro-2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (1.0 g, 5.0 mmol), potassium carbonate (1.65 g, 12 mmol), and 6-methyl-2-sulfanylpyrimidin-4-ol (560 mg, 4.0 mmol) were mixed in acetone (20 mL). The mixture was stirred at room temperature overnight. Acetone was then removed under reduced pressure. The crude solid was purified by column chromatography to provide the title compound as a white solid (850 mg, 79% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.20 (s, 3H), 3.60 (s, 3H), 4.51 (s, 2H), 6.04 (br, 1H), 6.93 (s, 1H); M+ 271.

후처리

  1. customAcetone was then removed under reduced pressure
  2. customThe crude solid was purified by column chromatography

출처 및 근거

ORD 기록
ord-4aa706d1948e4be08531e647278a6beb
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040538B2

반응 노트

불러오는 중…