Diethylamine → Methyl 2-chloro-6-[(diethylamino)methyl]benzoate

HRID 577215노트

반응식

HRID 577215 반응식
Br[CH2:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:4]=1[C:5]([O:7][CH3:8])=[O:6].[CH2:14]([NH:16][CH2:17][CH3:18])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:3]([CH2:2][N:16]([CH2:17][CH3:18])[CH2:14][CH3:15])[C:4]=1[C:5]([O:7][CH3:8])=[O:6]

참가 물질

5

반응물 3

HCID 8021DiethylamineHCID 11430Potassium CarbonateHCID 22935208Methyl 2-(bromomethyl)-6-chlorobenzoate

생성물 1

HCID 59589357Methyl 2-chloro-6-[(diethylamino)methyl]benzoate수율 99.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of methyl 2-(bromomethyl)-6-chlorobenzoate (4.0 g, 15.6 mmol), diethylamine (5 mL, 48.1 mmol), and potassium carbonate (4.3 g, 31.2 mmol) in acetone (60 mL) was stirred at room temperature for 2 days. The solid material was removed by filtration. The filtrate was recovered, evaporated, and dried in vacuo, affording methyl 2-chloro-6-[(diethylamino)methyl]benzoate (3.97 g, 99% yield), which was used without further purification.

후처리

  1. customThe solid material was removed by filtration
  2. customThe filtrate was recovered
  3. customevaporated
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-cec46471cd2e461080a66033527a5ab4
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040538B2

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