Triethylamine → HCID 178430797, 화합물

HRID 577219노트

반응식

HRID 577219 반응식
Br[CH2:2][C:3]1[C:8]([Cl:9])=[CH:7][N:6]=[CH:5][C:4]=1[Cl:10].[CH3:11][C:12]1[C:13]([OH:19])=[N:14][C:15]([SH:18])=[N:16][CH:17]=1.C(N(CC)CC)C>C(O)C>[Cl:10][C:4]1[CH:5]=[N:6][CH:7]=[C:8]([Cl:9])[C:3]=1[CH2:2][S:18][C:15]1[N:14]=[C:13]([OH:19])[C:12]([CH3:11])=[CH:17][N:16]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 222277664-(Bromomethyl)-3,5-dichloropyridineHCID 178430804HCID 178430804, 화합물

생성물 1

HCID 178430797HCID 178430797, 화합물수율 100.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a mixture of 4-(bromomethyl)-3,5-dichloropyridine (1.0 g, 4.15 mmol) and 5-methyl-2-sulfanylpyrimidin-4-ol (0.38 g, 2.69 mmol) in anhydrous ethanol (25 mL) at 0° C. was added triethylamine (1.67 g, 16.6 mmol). The reaction mixture was stirred at room temperature overnight. The solvent was evaporated, water was added, and the mixture was sonicated and then filtered. The solid was washed with water and hexane to provide 2-{[(3,5-dichloropyridin-4-yl)methyl]sulfanyl}-5-methylpyrimidin-4-ol (0.817 g, 65% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.90 (s, 3H), 4.66 (s, 2H), 7.99 (s 1H), 8.66 (s, 2H); M+ 302.5.

후처리

  1. customThe solvent was evaporated
  2. additionwater was added
  3. customthe mixture was sonicated
  4. filtrationfiltered
  5. washThe solid was washed with water and hexane

출처 및 근거

ORD 기록
ord-d39317d828014e3b9dac42cbd39f0472
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040538B2

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