Lithium borohydride → (2-Fluoro-3-morpholinophenyl)methanol
반응식
[F:1][C:2]1[C:16]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:15][CH:14]=[CH:13][C:3]=1[C:4](OCCOCCBr)=[O:5].[BH4-].[Li+]>C1COCC1>[F:1][C:2]1[C:16]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][OH:5]참가 물질
4
실험 절차
To a solution of 2-(2-bromoethoxy)ethyl 2-fluoro-3-morpholinobenzoate (450 mg, 1.2 mmol) in THF (5 mL) was added lithium borohydride (1.5 eq) and the reaction stirred at rt for 18 h. The reaction was quenched by addition of saturated NH4Cl (aq) and extracted with EtOAc. The organic phase was dried (Na2SO4), filtered and concentrated in vacuo. The resultant residue was purified by column chromatography (petroleum ether: EtOAc) to give (2-fluoro-3-morpholinophenyl)methanol.
후처리
- customThe reaction was quenched by addition of saturated NH4Cl (aq)
- extractionextracted with EtOAc
- dry with materialThe organic phase was dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe resultant residue was purified by column chromatography (petroleum ether: EtOAc)
출처 및 근거
- ORD 기록
- ord-5e1b829888cb42a3be37cfd3f8ef5800
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09040545B2
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