tert-butyl 4-nitro-1H-pyrazole-1-carboxylate → tert-butyl 4-amino-1H-pyrazole-1-carboxylate
반응식
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:8]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:8]=1참가 물질
4
실험 절차
tert-butyl 4-nitro-1H-pyrazole-1-carboxylate was stirred with palladium on carbon (10%, 170 mg) in ethanol (20 mL) under an atmosphere of hydrogen at 20° C. for 18 h. The palladium was removed by filtration and the solvent was removed in vacuo to give tert-butyl 4-amino-1H-pyrazole-1-carboxylate (1.48 g). 1H NMR (d6-DMSO) δ 7.35 (d, 1H), 7.33 (d, 1H), 4.40 (s, 2H), 1.54 (s, 9H).
후처리
- customThe palladium was removed by filtration
- customthe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-04f9edca0c134f42a0c0f9eff08eb84a
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09040545B2
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