HCID 86723802, 화합물 → 7-bromo-6-methyl-3,4-dihydro-1,4-benzoxazepin-5(2H)-one
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8](CC3C=CC(OC)=CC=3)[C:7](=[O:21])[C:6]=2[C:22]=1[CH3:23]>C(O)(C(F)(F)F)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][NH:8][C:7](=[O:21])[C:6]=2[C:22]=1[CH3:23]참가 물질
3
실험 절차
A mixture of 7-bromo-4-(4-methoxybenzyl)-6-methyl-3,4-dihydro-1,4-benzoxazepin-5(2H)-one (130c, 2.8 g, 7.4 mmol) in TFA (30 mL) was refluxed for 14 hours. The reaction mixture was concentrated under vacuum. The residue was purified by column chromatography (petroleum ether/EtOAc, 3/1) to give 7-bromo-6-methyl-3,4-dihydro-1,4-benzoxazepin-5(2H)-one (7-bromo-6-methyl-3,4-dihydro-1,4-benzoxazepin-5(2H)-one (130d, 1.2 g, 63%) as a brown solid.
후처리
- temperaturewas refluxed for 14 hours
- concentrationThe reaction mixture was concentrated under vacuum
- customThe residue was purified by column chromatography (petroleum ether/EtOAc, 3/1)
출처 및 근거
- ORD 기록
- ord-0f6a31b826034ecc8d1e61cbec3516ae
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09040515B2
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