Potassium Hydroxide → 2-Amino-5,6-bis(methoxymethyl)indane

HRID 577623

반응식

HRID 577623 반응식
[OH-].[K+].FC(F)(F)C([NH:7][CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH2:20][O:21][CH3:22])=[C:13]([CH2:17][O:18][CH3:19])[CH:14]=2)[CH2:9]1)=O>O.CO>[NH2:7][CH:8]1[CH2:9][C:10]2[C:15](=[CH:14][C:13]([CH2:17][O:18][CH3:19])=[C:12]([CH2:20][O:21][CH3:22])[CH:11]=2)[CH2:16]1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 224992202-(Trifluoroacetylamino)-5,6-bis(methoxymethyl)indane

생성물 1

HCID 668228442-Amino-5,6-bis(methoxymethyl)indane

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of potassium hydroxide (150 mg, 2.60 mmol) in water (0.5 ml) is added to a solution of 2-(trifluoroacetylamino)-5,6-bis(methyoxymethyl)indane (240 mg, 0.75 mmol) in methanol (3 mL) and the mixture is heated at reflux for 2.5 hours. The solvent was removed in vacuo and the residue is partitioned between aqueous sodium hydroxide (10 mL) and ethyl acetate (20 mL). The organic extract is dried (MgSO4) and the solvent is removed in vacuo to leave the product as a dark oil.

후처리

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 2.5 hours
  3. customThe solvent was removed in vacuo
  4. customthe residue is partitioned between aqueous sodium hydroxide (10 mL) and ethyl acetate (20 mL)
  5. extractionThe organic extract
  6. dry with materialis dried (MgSO4)
  7. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-71990a4097d54693a9fdff13494d3d22
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040559B2

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