2,2-Dimethoxypropane → HCID 67356722, 화합물

HRID 577827노트

반응식

HRID 577827 반응식
[F:1][C:2]1[C:9]([F:10])=[C:8]([F:11])C=C[C:3]=1[CH:4]=O.[CH3:12][O:13][C:14]([O:17][CH3:18])(C)[CH3:15]>CCOCC.CC1C=CC(S(O)(=O)=O)=CC=1>[CH3:12][O:13][CH:14]([O:17][CH3:18])[C:15]1[CH:4]=[CH:3][C:2]([F:1])=[C:9]([F:10])[C:8]=1[F:11]

참가 물질

5

반응물 2

HCID 64952,2-DimethoxypropaneHCID 5192262,3,4-Trifluorobenzaldehyde

생성물 1

HCID 67356722HCID 67356722, 화합물수율 71.7%

시약·촉매·용매 2

HCID 6101p-Toluenesulfonic acid촉매HCID 3283Diethyl Ether용매

실험 절차

A solution of 2,3,4-trifluorobenzaldehyde (25 g, 156.16 mmol), 2,2-dimethoxypropane (58.1 ml, 468.48 mmol), and 4-methylbenzenesulfonic acid (0.269 g, 1.56 mmol) was stirred at room temperature overnight. The reaction mixture diluted with ether and washed successively with aq. sodium bicarbonate solution, water, and brine. The organic layer dried over sodium sulfate and concentrated. The residue was distilled under high vacuum to give the title compound (23.07 g, 71.7%).

후처리

  1. washwashed successively with aq. sodium bicarbonate solution, water, and brine
  2. dry with materialThe organic layer dried over sodium sulfate
  3. concentrationconcentrated
  4. distillationThe residue was distilled under high vacuum

출처 및 근거

ORD 기록
ord-73668a9afa6d497f8d3d0788b8be06b6
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040528B2

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