홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Iodide → 6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-7-methyl-3-(1,3-thiazol-2-yl)-1,2-benzoxazole-5-carboxylic acid

HRID 577961
노트
인쇄 미리보기

반응식

HRID 577961 반응식
C[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([N:11]2[CH2:16][C@H:15]([CH3:17])[O:14][C@H:13]([CH3:18])[CH2:12]2)[C:5]([CH3:19])=[C:4](F)[C:3]=1[C:21](=[N:27][OH:28])[C:22]1[S:23][CH:24]=[CH:25][N:26]=1.C([O-])([O-])=O.[K+].[K+].[I-].[K+]>CN(C=O)C>[CH3:18][C@H:13]1[O:14][C@@H:15]([CH3:17])[CH2:16][N:11]([C:6]2[C:7]([C:8]([OH:10])=[O:9])=[CH:2][C:3]3[C:21]([C:22]4[S:23][CH:24]=[CH:25][N:26]=4)=[N:27][O:28][C:4]=3[C:5]=2[CH3:19])[CH2:12]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 136385151methyl 2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[(hydroxyimino)(1,3-thiazol-2-yl)methyl]-3-methylbenzoic acid2회

생성물 1

HCID 673582146-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-7-methyl-3-(1,3-thiazol-2-yl)-1,2-benzoxazole-5-carboxylic acid

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A solution of methyl 2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[(hydroxyimino)(1,3-thiazol-2-yl)methyl]-3-methylbenzoic acid (Intermediate 195, 0.31 g, 0.8 mmol), K2CO3 (0.4 g, 2.3 mmol) and potassium iodide (0.03 g, 0.2 mmol) in DMF (10 mL) was heated at 130° C. for 12 hours. Solvents were removed under vacuum and the residue was treated with 1.5N hydrochloric acid and extracted with ethyl acetate, which was dried over sodium sulfate. Removal of solvent by vacuum afforded product. Yield: 0.18 g (62%).

후처리

  1. customSolvents were removed under vacuum
  2. additionthe residue was treated with 1.5N hydrochloric acid
  3. extractionextracted with ethyl acetate, which
  4. dry with materialwas dried over sodium sulfate
  5. customRemoval of solvent by vacuum
  6. customafforded product

출처 및 근거

ORD 기록
ord-3d409dd2d08346c1850f4baae389c38c
출처 데이터셋
uspto-grants-2015_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09040528B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트