Ethanol → Ethyl 4,5-diamino-2-ethoxy-benzoate

HRID 578057노트

반응식

HRID 578057 반응식
C([NH:8][C:9]1[C:19]([N+:20]([O-])=O)=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]([O:23][CH2:24][CH3:25])[CH:10]=1)C1C=CC=CC=1.C(O)C>[Pd].C1COCC1>[NH2:8][C:9]1[C:19]([NH2:20])=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]([O:23][CH2:24][CH3:25])[CH:10]=1

참가 물질

5

반응물 2

HCID 702EthanolHCID 67233615Ethyl 4-benzylamino-2-ethoxy-5-nitro-benzoate

생성물 1

HCID 67229822Ethyl 4,5-diamino-2-ethoxy-benzoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

Palladium on charcoal (3.50 g 10%) was added to the product obtained at (655c) (16.7 g, 46.1 mmol) in 200 mL THF with 200 mL ethanol and the mixture was hydrogenated using a Parr apparatur at 60 psi H2 pressure and 50° C. for 3 h. The mixture was filtered, washed with ethanol and the filtrate concentrated i. vac. The residue was triturated with dichloromethane and evaporated to dryness. The product was reacted without further purification.

후처리

  1. customat 60 psi H2 pressure and 50° C.
  2. customfor 3 h
  3. filtrationThe mixture was filtered
  4. washwashed with ethanol
  5. concentrationthe filtrate concentrated i
  6. customThe residue was triturated with dichloromethane
  7. customevaporated to dryness
  8. customThe product was reacted without further purification

출처 및 근거

ORD 기록
ord-f2236cc87619431e88883eb50219acde
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040565B2

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