[F:1][C:2]([F:6])([F:5])[CH2:3][OH:4].[NH2:7][C:8]1[C:18]([N+:19]([O-:21])=[O:20])=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:10](F)[CH:9]=1.O>C1COCC1>[NH2:7][C:8]1[C:18]([N+:19]([O-:21])=[O:20])=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:10]([O:4][CH2:3][C:2]([F:6])([F:5])[F:1])[CH:9]=1Potassium tert.-butylate (0.97 g, 8.7 mmol) was added to 2,2,2-trifluoroethanol (0.63 mL, 8.8 mmol) in 20 mL THF at ambient temperature and stirred for 10 min. Then the mixture was cooled to 5° C. and ethyl 4-amino-2-fluoro-5-nitro-benzoate (1.80 g, 7.9 mmol) in 20 mL THF was added and stirred for 1 h at 5° C. Then the mixture was poured into water, extracted with ethyl acetate, the combined organic layers dried over MgSO4 and evaporated to dryness.
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