Acetyl chloride → HCID 68750450, 화합물
반응식
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:16][CH:17]([F:19])[F:18])=[C:10]([CH:15]=1)[C:11]([O:13][CH3:14])=[O:12]>C1COCC1>[C:1]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([O:16][CH:17]([F:18])[F:19])=[C:10]([CH:15]=1)[C:11]([O:13][CH3:14])=[O:12])(=[O:3])[CH3:2]참가 물질
4
실험 절차
Acetylchloride (1.8 mL, 25.3 mmol) in 25 mL THF was added to a mixture of methyl 5-amino-2-difluoromethoxy-benzoate (5.40 g, 24.9 mmol) with TEA (4.5 mL, 32.4 mmol) in 50 mL THF and the resulting mixture stirred for 15 min at ambient temperature. The mixture was filtered and the filtrate concentrated i. vac. The residue was mixed with acetonitrile and water, concentrated i. vac. and the solid filtered off. It was washed with water and dried at 40° C.
후처리
- filtrationThe mixture was filtered
- concentrationthe filtrate concentrated i
- additionThe residue was mixed with acetonitrile and water
- concentrationconcentrated i
- filtrationand the solid filtered off
- washIt was washed with water
- customdried at 40° C.
출처 및 근거
- ORD 기록
- ord-81c13605128a4902bf26b9d78d10fd41
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09040565B2
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