Ammonia → 5-(3-(Pyridin-3-yl)-1,2,4-oxadiazol-5-yl)pyridin-3-ol

HRID 578088

반응식

HRID 578088 반응식
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[OH:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([CH:20]=1)[C:17](O)=O.N>>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:3]2[N:10]=[C:17]([C:16]3[CH:20]=[C:12]([OH:11])[CH:13]=[N:14][CH:15]=3)[O:1][N:2]=2)[CH:5]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 340375-Hydroxynicotinic acidHCID 308113N-Hydroxynicotinimidamide

생성물 1

HCID 597587445-(3-(Pyridin-3-yl)-1,2,4-oxadiazol-5-yl)pyridin-3-ol

실험 절차

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 5-hydroxynicotinic acid (Matrix Scientific). 1H NMR (300 MHz, DMSO-d6) δ 7.66 (ddd, J=8.0, 4.9, 1.0 Hz, 1H), 7.86 (dd, J=2.7, 2.0 Hz, 1H), 8.31-8.55 (m, 2H), 8.83 (s, 2H), 9.26 (s, 1H) ppm; MS (DCI/NH3) m/z 241 (M+H)+.

출처 및 근거

ORD 기록
ord-a7b833d40f68495d94d21f7ec6bf4046
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040568B2

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