Ammonia → 5-(2,5-Difluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole

반응식

[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:13]=1[C:14](O)=O.N>>[F:11][C:12]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:13]=1[C:14]1[O:1][N:2]=[C:3]([C:4]2[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=2)[N:10]=1

참가 물질

반응물 3

HCID 222Ammonia

HCID 763392,5-Difluorobenzoic acid

HCID 308113N-Hydroxynicotinimidamide

생성물 1

HCID 670263035-(2,5-Difluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole

실험 절차

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 2,5-difluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.41-7.56 (m, 2H), 7.65 (ddd, J=7.9, 5.0, 1.0 Hz, 1H), 7.98-8.04 (m, 1H), 8.57 (dt, J=8.0, 1.9 Hz, 1H), 8.75 (dd, J=5.2, 1.6 Hz, 1H), 9.31 (dd, J=2.0, 0.8 Hz, 1H); MS (DCI/NH3) m/z 260 (M+H)+.

출처 및 근거

ORD 기록: ord-5cc9fe56f9b94c6ebb2cd37bbc1651c6
출처 데이터셋: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09040568B2

반응 노트

불러오는 중…