Ammonia → 3-(5-(5-Bromopyridin-3-yl)-1,2,4-oxadiazol-3-yl)benzonitrile

HRID 578191노트

반응식

HRID 578191 반응식
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6](=[N:8][OH:9])[NH2:7])#[N:2].[Br:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([CH:22]=1)[C:19](Cl)=O.N>>[Br:13][C:14]1[CH:22]=[C:18]([C:19]2[O:9][N:8]=[C:6]([C:5]3[CH:4]=[C:3]([CH:12]=[CH:11][CH:10]=3)[C:1]#[N:2])[N:7]=2)[CH:17]=[N:16][CH:15]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 27812235-Bromonicotinoyl chlorideHCID 573689333-Cyano-N-hydroxy-benzamidine

생성물 1

HCID 670263213-(5-(5-Bromopyridin-3-yl)-1,2,4-oxadiazol-3-yl)benzonitrile

실험 절차

The title compound was prepared according to the procedure of Example 4B using 3-cyano-N′-hydroxybenzimidamide and 5-bromonicotinoyl chloride (Alfa). 1H NMR (300 MHz, DMSO-d6) δ 7.67 (m, 1H), 7.74 (m, 1H), 8.41 (m, 1H), 8.49 (m, 1H), 8.64 (s, 1H), 8.93 (s, 1H), 9.4 (s, 1H) ppm; MS (DCI/NH3) m/z 327 (M+H)+.

출처 및 근거

ORD 기록
ord-ee521141ac0e42dc8ff1f32d1b8c60ea
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040568B2

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