Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-tert-Butyl-1H-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Tetramethoxypropane | HCID 66019 | — |
| 반응물 | tert-Butylhydrazine monohydrochloride | HCID 81889 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-tert-Butyl-1H-pyrazole | HCID 13469815 | 89.1% |
반응 단계
A mixture of 1,1,3,3-tetramethoxypropane (3.7 g, 22.6 mmol), tert-butylhydrazine hydrochloride (2.8 g, 22.6 mmol), and conc. HCl (6 mL, 72 mmol) in EtOH (30 mL) was heated at reflux overnight. The reaction mixture was poured into water and the resulting mixture was extracted with ether (30 mL×3). The combined organics was washed with brine (20 mL), dried over MgSO4, and concentrated under reduced pressure to afford 1-tert-butyl-1H-pyrazole as a white solid (2.5 g, 89%). MS (ESI) m/z: 125 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434725B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-6a335cf3c39a4015825d004aca41beae |
| 출처 메모 | uspto-grants-2016_09 |