HCID 66762054, 화합물 → HCID 66763583, 화합물

HRID 578667노트

반응식

HRID 578667 반응식
C(OC(=O)[NH:10][CH2:11][CH2:12][C@@H:13]([NH:20][C:21]1[C:30]2[C:25](=[C:26]([C:31](=[O:33])[NH2:32])[CH:27]=[CH:28][CH:29]=2)[N:24]=[CH:23][N:22]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)C1C=CC=CC=1>CCO.[Pd]>[NH2:10][CH2:11][CH2:12][CH:13]([NH:20][C:21]1[C:30]2[C:25](=[C:26]([C:31]([NH2:32])=[O:33])[CH:27]=[CH:28][CH:29]=2)[N:24]=[CH:23][N:22]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 1

HCID 66762054HCID 66762054, 화합물

생성물 1

HCID 66763583HCID 66763583, 화합물수율 54.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

[(R)-3-(8-Carbamoyl-quinazolin-4-ylamino)-3-phenyl-propyl]-carbamic acid benzyl ester (20 mg, 0.04 mmol) was dissolved in EtOH (5 mL) and treated with 5% Pd/C under 1 atm of H2. Upon completion the reaction was filtered through a pad of celite, and the pad was washed with EtOH. The crude material was purified by silica gel (10% MeOH/CH2Cl2) to afford the desired compound (7 mg, 50%). LCMS (ESI) 322 (M+H)

후처리

  1. filtrationUpon completion the reaction was filtered through a pad of celite
  2. washthe pad was washed with EtOH
  3. customThe crude material was purified by silica gel (10% MeOH/CH2Cl2)

출처 및 근거

ORD 기록
ord-a1d20baf37d849f298b30cd68574ea95
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040560B2

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