참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Bromo-6-fluoropyridine | HCID 639438 | — |
| 반응물 | tert-butyl N-(6-methylpiperidin-3-yl)carbamate | HCID 42609251 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | tert-butyl N-[1-(6-bromo-2-pyridyl)-6-methyl-3-piperidyl]carbamate | HCID 86707072 | 39% |
반응 단계
A solution containing 2-bromo-6-fluoropyridine (0.95 mL, 6.65 mmol and tert-butyl 6-methylpiperidin-3-ylcarbamate (750 mg, 3.32 mmol) in methyl sulfoxide 5.0 ml was heated 95° C. 18 h. The reaction was quenched with water then extracted with EtOAc. The organic layers was dried with sodium sulfate, filtered, and concentrated in vacuum. The crude product was purified by flash chromatography (EtOAc/Heptane eluted at 30% EtOAc) to give tert-butyl N-[1-(6-bromo-2-pyridyl)-6-methyl-3-piperidyl]carbamate (480 mg) in 39% yield. MS (ESI) m/z: 371.2
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09434725B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-3d401b61bbcc445dbb22ecc949716f4e |
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| 출처 메모 | uspto-grants-2016_09 |
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