5-((1H-1,2,4-Triazol-1-yl)methyl)-3-bromo-2-(difluoromethoxy)pyridine → 2-Methoxy-3-(1H-pyrazol-4-yl)-5-(1H-1,2,4-triazol-1-ylmethyl)pyridine

반응식

[N:1]1([CH2:6][C:7]2[CH:8]=[C:9](Br)[C:10]([O:13][CH:14](F)F)=[N:11][CH:12]=2)[CH:5]=[N:4][CH:3]=[N:2]1.[NH:18]1[CH:22]=[CH:21][C:20](B(O)O)=[N:19]1>>[CH3:14][O:13][C:10]1[C:9]([C:21]2[CH:22]=[N:18][NH:19][CH:20]=2)=[CH:8][C:7]([CH2:6][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:12][N:11]=1

참가 물질

반응물 2

HCID 904149845-((1H-1,2,4-Triazol-1-yl)methyl)-3-bromo-2-(difluoromethoxy)pyridine

HCID 178514837HCID 178514837, 화합물

생성물 1

HCID 904170652-Methoxy-3-(1H-pyrazol-4-yl)-5-(1H-1,2,4-triazol-1-ylmethyl)pyridine

실험 절차

The title compound was prepared in a manner analogous to Example 4, from Intermediate 13 and the appropriate pyrazole boronic acid. 1H NMR (400 MHz, DMSO-d6) δ 8.69 (s, 1H), 8.07 (s, 1H), 8.01 (q, J=2.3 Hz, 2H), 7.99 (s, 1H), 5.37 (s, 1H), 3.94 (s, 3H), 2.52 (s, 1H). [M+H]=257.26.

출처 및 근거

ORD 기록: ord-fccd3409504d4b35996393fa6e1f8f1c
출처 데이터셋: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09040692B2

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