Tributylvinyltin → 1-(3-Chloro-5-vinyl-2-pyridyl)cyclopropanecarbonitrile

HRID 578866노트

반응식

HRID 578866 반응식
Br[C:2]1[CH:3]=[C:4]([Cl:13])[C:5]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[CH:14]([Sn](CCCC)(CCCC)CCCC)=[CH2:15]>C1(C)C=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Cl:13][C:4]1[C:5]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)=[N:6][CH:7]=[C:2]([CH:14]=[CH2:15])[CH:3]=1

참가 물질

5

반응물 2

HCID 81998TributylvinyltinHCID 715592791-(5-Bromo-3-chloropyridin-2-yl)cyclopropane-1-carbonitrile

생성물 1

HCID 895443761-(3-Chloro-5-vinyl-2-pyridyl)cyclopropanecarbonitrile수율 50.9%

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 1140Toluene용매

실험 절차

4.7 g of 1-(5-Bromo-3-chloro-pyridin-2-yl)-cyclopropanecarbonitrile (step 2 of PREPARATION EXAMPLE 3) was dissolved in 40 ml anhydrous toluene, then 700 mg of tetrakis(triphenylphosphine)palladium(0) and 9.0 g vinyltributylstannane were added under a nitrogen atmosphere. The reaction mixture was heated on reflux for 3 hours. After cooling to ambient temperature, the reaction mixture was filtered, the filtrate was diluted with 100 ml of ethyl acetate, then washed with water and with saturated potassium fluoride solution. The organic layer was dried over anhydrous sodium sulfate and concentrated. Crude material was obtained as a dark oil, which was purified by flash chromatography on silica gel with heptane/ethyl acetate as a solvent. Thus, 1.9 g of 1-(3-chloro-5-vinyl-2-pyridyl)cyclopropanecarbonitrile was obtained as a yellow oil. 1H-NMR (CDCl3): 8.40 ppm (s, 1H), 7.78 ppm (s, 1H), 6.67 ppm (dd, 1H), 5.87 ppm (d, 1H), 5.50 ppm (d, 1H), 1.77 ppm (m, 2H), 1.63 ppm (m, 2H).

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureon reflux for 3 hours
  3. filtrationthe reaction mixture was filtered
  4. additionthe filtrate was diluted with 100 ml of ethyl acetate
  5. washwashed with water and with saturated potassium fluoride solution
  6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  7. concentrationconcentrated
  8. customCrude material was obtained as a dark oil, which
  9. customwas purified by flash chromatography on silica gel with heptane/ethyl acetate as a solvent

출처 및 근거

ORD 기록
ord-2d544ae3519748b3bf2348f5d3041561
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040708B2

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