Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzylamine → N-Benzyl-6-chloro-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzylamine | HCID 7504 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 6-Chloronicotinic acid | HCID 79222 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-Benzyl-6-chloro-nicotinamide | HCID 857488 | 636.4% |
반응 단계
Combined 6-chloronicotinic acid (20 g, 12.74 mmol) and HATU (72.6 g, 19.1 mmol) in DMF (200 mL) and added triethylamine (38.6 g, 38.2 mmol) drop wise, followed by benzylamine (16.36 g, 15.28 mmol) and stirred at room temperature overnight. Then the reaction mixture was poured into ice-water and stirred for 20 minutes to give a solid. The solid was collected by filtration, washed with water (30 mL×2), and dried under reduced pressure to give the title compound (20 g, 64%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09040522B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-1ac1805544854fac96d811f5df2bf6da |
| 출처 메모 | uspto-grants-2015_05 |