2-(Trifluoromethoxy)ethan-1-amine hydrochloride → HCID 178426446, 화합물

HRID 579060노트

반응식

HRID 579060 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[CH:4]=1)#[N:2].Cl.[F:26][C:27]([F:33])([F:32])[O:28][CH2:29][CH2:30][NH2:31]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([NH:31][CH2:30][CH2:29][O:28][C:27]([F:33])([F:32])[F:26])=[O:21])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[CH:4]=1)#[N:2]

참가 물질

3

반응물 2

HCID 448908072-(Trifluoromethoxy)ethan-1-amine hydrochlorideHCID 178426451HCID 178426451, 화합물

생성물 1

HCID 178426446HCID 178426446, 화합물

실험 절차

The title compound was prepared in a manner similar to Example 227 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 2-(trifluoromethoxy)ethanamine hydrochloride. 1H NMR (400 MHz, DMSO-d6) δ 2.36 (s, 3 H) 3.55 (q, J=5.3 Hz, 2 H) 4.16 (t, J=5.3 Hz, 2 H) 7.59 (d, J=7.8 Hz, 1 H) 7.66 (s, 1 H) 7.71 (br. s., 1 H) 8.14 (br. s., 1 H) 8.36 (d, J=7.3 Hz, 1 H) 8.84-8.88 (m, 1 H) 8.93 (t, J=4.4 Hz, 1 H) 13.18 (br. s., 1 H). MS m/z [M+H]+ 432.4.

출처 및 근거

ORD 기록
ord-1381b5d668a34ec4ab01da9d23f08f9a
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040522B2

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